Sesquiterpene lactones (SLs) are a structurally diverse group of secondary metabolites primarily produced by plants, particularly within the Asteraceae family. These compounds play significant roles in plant defense and have been extensively studied for their wide range of biological activities, including antiviral, antimicrobial, anti-inflammatory, and anticancer properties. This review focuses on the biosynthesis, structure-activity relationships, and biological activities of sesquiterpene lactones, with an emphasis on their antiviral potential. SLs exert their antiviral effects by targeting viral entry, replication, and other critical stages of the viral life cycle. Notable examples include guaianolides and germacranolides, which have demonstrated promising activity against viruses such as hepatitis C, influenza, and herpes simplex. This review also emphasizes the potential of sesquiterpene lactones as promising scaffolds for antiviral drug development, positioning these compounds as key candidates in combating viral infections.

Makaleyi görüntüle

Effect of different storage conditions (room temperature, 4°C, and -15°C) and different storage periods over 24 months on seed germination in Swertia chirayita collected from different altitudes in Sikkim Himalaya was determined. Multivariate ANOVA revealed significant (P < 0.0001) effect of storage condition and storage period on seed germination and mean germination time. Seed germination percentage significantly (P < 0.01) varied between 87.78% (Sc5) and 100% (Sc2) during initial testing. Comparatively, high seed germination, low mean germination time, and low rate of fall in seed germination percentage in seeds stored at 4°C over different storage period were recorded. In addition, above 50% seed germination in majority of the populations even after 24 months of storage suggests 4°C as the most appropriate storage condition for long-term storage of seeds of S. chirayita.

Makaleyi görüntüle

This index lists all 3367 normalized pharmacological activity terms appeared in the encyclopedia in alphabetical order and a number code sequence of the related compounds follows the bold term immediately.

Makaleyi görüntüle