Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.

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Hemanthamine [466-75-1] C17H19NO4 (301.35). mp 203~203.5ºC, [a]D 25 = +19.7º (c = 3.8, methanol), [a]D 25 = +33 (c = 1.25, CHCl3). Pharm: Antihypertensive (mild); antiretroviral and cytotoxic (ID50 = 0.8µg/mL, TC50 = 1.0µg/mL, TI50 (TC50/ID50) = 1.3)[5026].

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