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Kopsia Grandifolia
Bitki adı:
Kopsia Grandifolia
Bilimsel adı:
Kopsia grandifolia
Cins:
Kopsia
Familya:
Apocynaceae
Genel Bilgiler
Duke – Ethnobotany
Bu bitki için Duke Ethnobotany kaydı bulunamadı.
Bilimsel Araştırmalar
Pyrroloazocine alkaloids from the Kopsia genus exhibit structural complexity and pharmacological potential. We report the concise and asymmetric synthesis of a pentacyclic core from l-proline. The key features include a C-N-C chirality transfer process to prepare the α-tertiary amine intermediate enantioselectively, an eight-membered C ring-forming Friedel-Crafts reaction at the indole C3 position, and a dearomative indole-Claisen rearrangement to form a bridged pentacyclic scaffold. This study provides a versatile platform for the divergent synthesis of diverse Kopsia alkaloids.
Makaleyi görüntüle
Makaleyi görüntüle
The total synthesis of seven members of the lapidilectine and grandilodine family of alkaloids has been accomplished in racemic and enantiopure form without protection/deprotection of functional groups. The two key steps, an 8- endo-dig hydroarylation and a 6- exo-trig photoredox cyclization, were catalyzed using gold. A rationale for the formation of the cyclopropane ring of the lundurines is also provided.
Makaleyi görüntüle
Makaleyi görüntüle
Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.
Makaleyi görüntüle
Makaleyi görüntüle
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