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Rubia Cordifolia

Bitki adı: Rubia Cordifolia

Bilimsel adı: Rubia cordifolia

Cins: Rubia

Familya: Rubiaceae

Genel Bilgiler

Bilimsel Araştırmalar

Natural Products as Anticancer Agents: Current Status and Future Perspectives.

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds have been synthesized from natural products by modifying their structures or by using naturally occurring compounds as building blocks in the synthesis of these compounds for various purposes in different fields, such as biology, medicine, and engineering. Multiple modern and costly treatments have been applied to combat cancer and limit its lethality, but the results are not significantly refreshing. Natural products, which are a significant source of new therapeutic drugs, are currently being investigated as potential cytotoxic agents and have shown a positive trend in preclinical research and have prompted numerous innovative strategies in order to combat cancer and expedite the clinical research. Natural products are becoming increasingly important for drug discovery due to their high molecular diversity and novel biofunctionality. Furthermore, natural products can provide superior efficacy and safety due to their unique molecular properties. The objective of the current review is to provide an overview of the emergence of natural products for the treatment and prevention of cancer, such as chemosensitizers, immunotherapeutics, combinatorial therapies with other anticancer drugs, novel formulations of natural products, and the molecular mechanisms underlying their anticancer properties.

Makaleyi görüntüle

Antidiabetic Potential of Medicinal Plants and Their Active Components.

Diabetes mellitus is one of the major health problems in the world, the incidence and associated mortality are increasing. Inadequate regulation of the blood sugar imposes serious consequences for health. Conventional antidiabetic drugs are effective, however, also with unavoidable side effects. On the other hand, medicinal plants may act as an alternative source of antidiabetic agents. Examples of medicinal plants with antidiabetic potential are described, with focuses on preclinical and clinical studies. The beneficial potential of each plant matrix is given by the combined and concerted action of their profile of biologically active compounds.

Makaleyi görüntüle

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects.

Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively reduces the quality of life in cancer patients. Natural products including crude extracts, bioactive components-enriched fractions and pure compounds prepared from herbs as well as herbal formulas have been proved to prevent and treat cancer. Of significant interest, some natural products can reduce chemotherapy and radiotherapy-induced oral mucositis, gastrointestinal toxicity, hepatotoxicity, nephrotoxicity, hematopoietic system injury, cardiotoxicity, and neurotoxicity. This review focuses in detail on the effectiveness of these natural products, and describes the possible mechanisms of the actions in reducing chemotherapy and radiotherapy-induced side effects. Recent advances in the efficacy of natural dietary supplements to counteract these side effects are highlighted. In addition, we draw particular attention to gut microbiotan in the context of prebiotic potential of natural products for the protection against cancer therapy-induced toxicities. We conclude that some natural products are potential therapeutic perspective for the prevention and treatment of chemotherapy and radiotherapy-induced side effects. Further studies are required to validate the efficacy of natural products in cancer patients, and elucidate potential underlying mechanisms.

Makaleyi görüntüle

Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action.

Many approaches to cancer management are often ineffective due to adverse reactions, drug resistance, or inadequate target specificity of single anti-cancer agents. In contrast, a combinatorial approach with the application of two or more anti-cancer agents at their respective effective dosages can achieve a synergistic effect that boosts cytotoxicity to cancer cells. In cancer, aberrant apoptotic pathways allow cells that should be killed to survive with genetic abnormalities, leading to cancer progression. Mutations in apoptotic mechanism arising during the treatment of cancer through cancer progression can consequently lead to chemoresistance. Natural compound mixtures that are believed to have multiple specific targets with minimal acceptable side-effects are now of interest to many researchers due to their cytotoxic and chemosensitizing activities. Synergistic interactions within a drug mixture enhance the search for potential molecular targets in cancer cells. Nonetheless, biased/flawed scientific evidence from natural products can suggest false positive therapeutic benefits during drug screening. In this review, we have taken these factors into consideration when discussing the evidence for these compounds and their synergistic therapeutic benefits in cancer. While there is limited evidence for clinical efficacy for these mixtures, in vitro data suggest that these preparations merit further investigation, both in vitro and in vivo.

Makaleyi görüntüle

Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer.

Cancer prevention and treatment using traditional Chinese medicines have attracted increasing interest. This study characterizes antioxidant activity and phenolic compounds of traditional Chinese medicinal plants associated with anticancer, comprising 112 species from 50 plant families. The improved ABTS(*+) method was used to systematically assess the total antioxidant capacity (Trolox equivalent antioxidant capacity, TEAC) of the medicinal extracts. The TEAC values and total phenolic content for methanolic extracts of herbs ranged from 46.7 to 17,323 micromol Trolox equivalent/100 g dry weight (DW), and from 0.22 to 50.3 g of gallic acid equivalent/100 g DW, respectively. A positive, significant linear relationship between antioxidant activity and total phenolic content (all R(2) values>/=0.95) showed that phenolic compounds were the dominant antioxidant components in the tested medicinal herbs. Major types of phenolic compounds from most of the tested herbs were preliminarily identified and analyzed, and mainly included phenolic acids, flavonoids, tannins, coumarins, lignans, quinones, stilbenes, and curcuminoids. These medicinal herbs exhibited far stronger antioxidant activity and contained significantly higher levels of phenolics than common vegetables and fruits. Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents.

Makaleyi görüntüle

Duke Ethnobotany - Tamamlayıcı Kullanımlar

Abdomen

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Alterative

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Amenorrhea

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Anodyne

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Arthritis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Arthritis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Astringent

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Bactericide

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Blood

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Charm

Ülke: Lesotho

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Guillarmod

Kaynak: James A. Duke

Chest

Ülke: Lesotho

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Guillarmod

Kaynak: James A. Duke

Depurative

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Diuretic

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Divination

Ülke: Lesotho

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Guillarmod

Kaynak: James A. Duke

Dysmenorrhea

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Edema

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Emmenagogue

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Keys

Kaynak: James A. Duke

Emmenagogue

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Epistaxis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Fracture

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Hematemesis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Hemoptysis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Hemorrhage

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Hemostat

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Hemostat

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Keys

Kaynak: James A. Duke

Hyperglycemia

Ülke: Elsewhere

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Woi.9

Kaynak: James A. Duke

Inflammation

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Jaundice

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Jaundice

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Jaundice

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Keys

Kaynak: James A. Duke

Menorrhagia

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Paralysis

Ülke: Nepal

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Eb33: 191

Kaynak: James A. Duke

Paralysis

Ülke: Nepal

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Singh

Kaynak: James A. Duke

Piles

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Keys

Kaynak: James A. Duke

Refrigerant

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Rheumatism

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Rheumatism

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Keys

Kaynak: James A. Duke

Rheumatism

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Rheumatitis

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Nas

Kaynak: James A. Duke

Rhinosinusitis

Ülke: India

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Woi.9

Kaynak: James A. Duke

Skin

Ülke: Elsewhere

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Woi.9

Kaynak: James A. Duke

Tonic

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Tonic

Ülke: Elsewhere

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Woi.9

Kaynak: James A. Duke

Toothhpaste

Ülke: Lesotho

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Guillarmod

Kaynak: James A. Duke

Trauma

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hunan

Kaynak: James A. Duke

Tumor(Abdomen)

Ülke: India

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Hartwell

Kaynak: James A. Duke

Ulcer

Ülke: Nepal

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Eb33: 191

Kaynak: James A. Duke

Ulcer

Ülke: Nepal

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Singh

Kaynak: James A. Duke

Vermifuge

Ülke: Elsewhere

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Woi.9

Kaynak: James A. Duke

Vulnerary

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Bliss

Kaynak: James A. Duke

Wound

Ülke: China

Duke USEAGE: M

Taxon: Rubia cordifolia

Referans: Altschul

Kaynak: James A. Duke

Kaynaklar ve Görseller

File:Rubia cordifolia L. (16162380370).jpg

File:Rubia cordifolia-3-yercaud-salem-India.JPG

File:Rubia cordifolia-2-yercaud-salem-India.JPG

File:Rubia cordifolia-2-five road-yercaud-salem-India.JPG

File:Rubia cordifolia-1-yercaud-salem-India.JPG

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